WebEtoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular … Web17 okt. 2024 · Another mutant study in the CAP homology domain (critical role in DNA binding) of yeast topoisomerase II showed hypersensitivity of mutant strain overproducing ScTopo II-T744P enzyme to an intercalator m-AMSA and a non-intercalator CP-115,953; but not to etoposide as there are no differences in minimum lethal concentrations with …
Inhibition of topoisomerase IIα sensitizes FaDu cells to ionizing ...
WebEtoposide should only be given by slow intravenous infusion (see section 4.4 Special warnings and precautions for use, section 4.8 Adverse effects (undesirable effects)). Etoposide should not be administered by intrapleural or intraperitoneal injection. Etoposide must be diluted before administration. Resultant concentrations should not Web10 mei 2002 · The activation of p53 by etoposide resulted in the up-regulation of the pro-apoptotic protein Bax, a result that was prevented by the protein synthesis inhibitor cycloheximide. The increase in the content of Bax was followed by the translocation of this protein from the cytosol to the mitochondria, an event that was inhibited by furosemide, a … chiropractor in pearsall tx
Etoposide - Wikipedia
WebEtoposide is relatively cell cycle specific, and it affects cells in the S and G2 phases of cell division. The dose-limiting toxicity is myelosuppression, with neutropenia the principal … WebEtopophos is a cancer medicine used to treat: testicular cancer, lung cancer, ovarian cancer, gestational trophoblastic neoplasia (a rare tumour of the womb that occurs during … WebEtoposide is contraindicated in severe hepatic dysfunction, and it should be used with caution in patients with mild to moderate hepatic impairment. Renal impairment Since … chiropractor in pearland