Integrin and ferroptosis
Nettet4. des. 2024 · The integrin α6β4 represses ACSL4 to inhibit ferroptosis. Expression of ACSL4 was assessed by qPCR (A) and immunoblotting (B) in vector control and β4 … Nettet17. aug. 2024 · Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of lipid-targeting reactive oxygen species that …
Integrin and ferroptosis
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NettetTo date, little is known about the mechanisms that protect ECM-detached tumor cells from ferroptosis and thus survive. Brown et al. reported that a6b4 integrin promotes … Nettet14. feb. 2024 · Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer Cancers (Basel). 2024 Feb 14 ... Moreover, using gene manipulation approaches and pharmacological inhibitors, we show that this "αvβ3 integrin addiction" can be targeted to reverse TKI resistance.
NettetAutophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to recycle metabolic substrates. Autophagy is modulated by many factors, such as nutritional … Nettet4. des. 2024 · The α6β4 integrin promotes evasion of ferroptosis induced by erastin. (A) The β4-integrin subunit was depleted in MCF10-A and SUM-159 cells by …
Nettet7. jan. 2024 · On the other hand, the nuclei in ferroptotic cells remain structural integrity, without condensation or chromatin margination [ 7, 13 ]. In some special cases, ferroptosis is also accompanied by the detachment and aggregation of cells, as well as the increase of autophagosomes [ 14 ]. Nettet2. des. 2024 · Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway (e.g., decreased cysteine or glutamine uptake and …
Nettet2. jul. 2004 · The β 2 integrins are heterodimeric glycoproteins that exist in four forms. Each form is composed of a unique α-subunit, encoded by the CD11a, CD11b, CD11c, or CD11d gene, noncovalently associated with a common β-subunit encoded by …
Nettet3. feb. 2024 · Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. ... integrin α6β4 can mediate the activation of Src and STAT3, resulting in decreased expression of ACSL4 and suppression of ferroptosis. 57 ... do smart meters read gas and electricityNettetThe integrin α6β4 activates Src to inhibit ferroptosis. (A) Vector control and β4-depleted cells were assessed for phosphorylated (Y418) Src by immunoblotting 3 h after ECM detachment. Relative... city of santa ana job specsNettetDOI: 10.1016/j.bbadis.2024.166688 Corpus ID: 257573488; Platelet activation and ferroptosis mediated NETosis drives heme induced pulmonary thrombosis. @article{NaveenKumar2024PlateletAA, title={Platelet activation and ferroptosis mediated NETosis drives heme induced pulmonary thrombosis.}, author={Somanathapura K. … city of santa ana job descriptionsNettet29. jan. 2024 · Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid ... such as the integrin subunits α6 and β4 also protect against ferroptosis in breast cancer-derived ... do smart meters really save moneyNettet1. apr. 2024 · Ferroptosis, a form of iron-dependent programmed cell death, has recently been found to be involved in matrix-detached cancer cells. However, the molecular mechanisms by which ECM-detached cells escape ferroptosis are not fully understood. city of santa ana job opportunitiesNettet30. mar. 2024 · Ferroptosis is a newly discovered iron-dependent, non-apoptotic, programmed cell death mode , caused mainly by iron deposition, of ... proteoglycan syndecan-mediated signaling events, alpha9 beta1 integrin signaling events, interferon (IFN)-gamma pathway, and signaling events mediated by VEGFR1 and VEGFR2, etc ... city of santa ana jobs internshipsNettet10. apr. 2024 · Ferrostatin-1 (Fer-1), a ferroptosis inhibitor, alleviated TGF-β1-induced ferroptosis. In diabetic mice, kidney mRNA and protein expressions of xCT and GPX4 were reduced compared to control. do smart meters show vat