Laminin 10

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August undefined, 2024

WebImmunocytochemistry analysis of Laminin in HeLa cells. Samples were incubated in Laminin polyclonal antibody (Product # PA1-16730) followed by Alexa Fluor 488 … WebLaminin is produced by various cells throughout the human body, including epithelial cells, muscle cells, and fibroblasts. More

Recombinant human laminin-10 (alpha5beta1gamma1).

WebMay 15, 2003 · Laminin-10 was present in the basement membrane of elongating hair germs, when other laminins were downregulated, suggesting a role for laminin-10 in hair development. Treatment of human scalp xenografts with antibodies to laminin-10, or its receptor beta1 integrin, produced alopecia. WebDec 15, 2009 · Laminin heterotrimers are relatively large proteins (with molecular masses ranging from 400 to 900 kDa) and exist as cross-shaped molecules with two or three … dog spca

Re-investigating the Basement Membrane Zone of …

WebMar 21, 2024 · Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. WebAim: To assess laminin levels in the seminal plasma of infertile and fertile men, and to analyze the correlation of laminin levels with sperm count, age, sperm motility and semen volume. Methods: One hundred and twenty-five recruited men were equally divided into five groups according to their sperm concentration and clinical examination: fertile … dog spinal injury

Laminin 1 - an overview ScienceDirect Topics

Laminin - an overview ScienceDirect Topics

WebOct 17, 2012 · EHS laminin has the chain composition α1β1γ1 and is now referred to as laminin-111. 10 Laminins appear as cross-shaped molecules in rotary shadowing electron micrographs. 11,12 The long arm of the cross (~80 nm length) is an α-helical coiled coil formed from all three chains, whereas the three short arms (35–50 nm) are composed of … WebIn the present study, CAF-secreted TGF-β1 substantially increased the expression of laminin γ2 (Ln-γ2; encoded by the LAMC2 gene) in NSCLC and ESCC cells via c-Jun N … dog spinachWebAim: To evaluate the expression of laminin in various grades of oral squamous cell carcinoma (OSCC) in order to determine whether this protein can be used as a marker for early detection and elucidation of oral cancer. Materials and methods: Immunohistochemical staining for laminin was done on 60 selected archival blocks of histopathologically ... dog spinal stroke

"WebLaminin-1. Laminins-1 and -10 seem to be the only two laminins expressed in early postimplantation embryos. Laminin-1 is the core laminin in the Reichert membrane, an … " - Laminin 10

Laminin 10

Trophoblast cells exhibit differential responses to laminin isoforms ...

WebLaminin Antibodies Antibodies that detect Laminin can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, Flow Cytometry and ELISA. These antibodies target Laminin in Human, Mouse, Rat, Mammalia and Invertebrate samples. WebAug 26, 2024 · This is the first report showing that Lu/BCAM, in the presence of its ligand laminin, is oncogenic in human urothelial cancers and may have potential as a novel therapeutic target. J Biomed Sci . 2024 Aug 26;24(1):61. doi: 10.1186/s12929-017-0360-x.

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WebApr 12, 2002 · The laminin (LN) family of large heterotrimeric extracellular matrix glycoproteins has multiple functions: LNs take part in the regulation of processes such as … WebThese results suggest that laminin-2, laminin-8, and laminin-10 are important components of tumor microvessels and may associate with breast tumor progression. Angiogenic switch from laminin-9 and laminin-11 to laminin-8 and laminin-10 first occurs in carcinomas in situ and becomes more pronounced w …

WebFurther, laminin-10/11 provided a proliferative signal for neonatal foreskin keratinocytes, adult breast skin keratinocytes, and even a human papillomavirus type-18 transformed tumorigenic keratinocyte cell line in vitro. Finally, laminin-10/11 was shown to stimulate keratinocyte migration in an in vitro wound healing assay. These results ... WebMethods: Laminin expression was evaluated in 31 cases of biopsy-proven OSCC by immunohistochemical staining and its association with prognosticators and the Brynes grading system was determined by appropriate statistical analysis. Results: We observed a significant increase in linear staining pattern (p < 0.001) at the tumour-host interface in ...

WebDec 12, 2013 · The biochemical composition of the internal and external basal laminae in the junctional epithelium differs significantly, and the precise cellular origin of their respective … WebLaminin-alpha 2 is widely expressed in the basement membrane of skeletal muscle, at neuromuscular synpases, extra-synaptically and in the myotendinous junctions. LAMA2 has been shown to bind to dystroglycan, which interacts with dystrophin and extra-cellular laminin. Recently mutations have been mapped to the LAMA2 gene that seem imply a …

WebOct 29, 2008 · Laminin is a protein that is part of the extracellular matrix in humans and animals. The extracellular matrix (ECM) lies outside of cells and provides support and attachment for cells inside organs (along with …

WebThis antibody is pan-specific and reacts well with all Laminin isoforms tested: Laminin-1 (alpha-1, beta-1, and gamma-1) and Laminin-2 (alpha-2, beta-1, and gamma-1). The antibody functionally inhibits Laminin in mouse and rat. It binds to Laminin and inhibits most, if not all, of its cell adhesion and growth promotive properties. dog spine curved upWebAntibodies that detect Laminin can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, Flow Cytometry and ELISA. … dog spine protrudingWebMay 22, 2024 · Laminin, Integrin, Electron microscopy, Conformational change INTRODUCTION Integrins are a family of cell adhesion receptors that mediate cell-cell and cell-extracellular matrix interactions and govern … dog spa snoqualmieWebLaminin 521 is a new anti-GBM disease pulmonary hemorrhage autoantibody target. Studies have shown that in anti-glomerular basement membrane disease, circulating … dog spay price ukWebMar 1, 2000 · Laminin-10/11, the laminin isoforms containing the alpha 5 chain, are major components of basement membranes of many fetal and adult tissues. Laminin-10/11 … dog spine anatomyWebJan 1, 2013 · Laminins (LMs) are abundant extracellular matrix (ECM) proteins present predominantly in basement membranes (BM). 1, 2 At least 16 isoforms have been described and named according to their specific trimeric combination of α, β and γ chains using the new nomenclature. 3 The existence of a LM-511 trimer (α5β1γ1, formerly LM-10) was first … dog spiralWeblaminin: [noun] a glycoprotein component of connective tissue basement membrane that promotes cell adhesion. dog spine x ray