Ototoxicity from cisplatin

Author: vgay

August undefined, 2024

WebJan 1, 2016 · Vikash Sewram. Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of … WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the …

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WebApr 7, 2024 · On 30 March 2024, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending … WebFrom these, doxorubicin, high-dose methotrexate, cisplatin, and, to a lesser extent, ifosfamide have emerged as the most active. Others such as ... et al. Prevention of … cff scc

Cisplatin-induced ototoxicity: From signaling network to …

WebJul 15, 2015 · Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with … WebApr 26, 2024 · An overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms, and risk factors, is presented and … WebApr 7, 2024 · Determining the mechanism behind this adverse effect could possibly aid in developing strategies to mitigate it. Potential mechanisms for cisplatin-induced ototoxicity include direct cytotoxicity from the platinum-containing agent, direct damage to DNA, or induction of apoptosis through mechanisms involving cell cycle arrest and/or generation … bwt cergy

FDA approves sodium thiosulfate to reduce the risk of ototoxicity ...

The Role of the Reactive Oxygen Species Scavenger Agent, …

WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the … WebJun 18, 2024 · Ototoxicity monitoring is uncommon in South Africa, despite the increased use of ototoxic medication to manage the burden of disease in the country. The … cff rtmWebCisplatin Ototoxicity. Cisplatin is a widely used and effective drug for the treatment of solid tumors ranging from ovarian, lung, head, and neck to testicular cancer. Dose limiting side … bwtc japan porcelain plate

"WebApr 9, 2024 · The European Commission will review the CHMP’s recommendation and issue a decision on the injection’s approval by early June 2024. The CHMP based its … " - Ototoxicity from cisplatin

Ototoxicity from cisplatin

Subclinical diagnosis of cisplatin-induced ototoxicity with …

Webhree survivors of childhood cancer treated with cisplatin at our Unit from 1991 to 2004 performed tympanometry, pure tone audiometry, transient otoacoustic emissions, and … WebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: …

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WebOtotoxicity hearing loss, ringing in the ears. Blood test abnormalities (low magnesium, low calcium, low potassium) ... Cisplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, carboplatin, other platinum-containing formulations or … WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of …

WebOct 27, 2024 · A mouse model with cisplatin-induced ototoxicity was used in addition to human samples from the ITMAT Biobank at the University of Pennsylvania. Mouse … WebJun 10, 2010 · Objective . Combined cisplatin (CDDP) and radiotherapy is increasingly being used to treat advanced head and neck cancers. As both CDDP and radiation can cause hearing loss, it is important to have a better understanding of the cellular and molecular ototoxic mechanisms involved in combined therapy. Procedure . The effects of CDDP, …

WebA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This hearing …

WebApr 9, 2024 · EU's CHMP Recommends Injection Against Pediatric Chemo-Induced Ototoxicity. Apr 9, 2024. Russ Conroy. Findings from 2 phase 3 trials support the recommendation to approve sodium thiosulfate to reduce the risk of cisplatin-related hearing loss in pediatric patients with solid tumors in Europe. The European Medicine …

WebJul 24, 2024 · Mechanisms of platinum ototoxicity. The hearing loss caused by cisplatin and carboplatin is due to degeneration of the cochlear hair cells and supporting cells (Rybak et al, Citation 2007; Brock et al, Citation 2012).The outer hair cells are damaged before the inner hair cells, and platinum initially affects hair cells at the base of the cochlea, where … bwt clipWebMar 5, 2024 · Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no … bwt chefWebJan 1, 2024 · Cisplatin ototoxicity is mainly manifested as cochlear toxicity, leading to hearing loss and tinnitus, and vestibular toxicity has rarely been reported. There are two … cffr websiteWebIn cisplatin-treated guinea pigs, pretreatment with A666-DEX-NP effectively preserved OHCs and showed significant hearing protection at 4, 8, and 16 kHz as compared to … cffseWebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative risk … bwt cleaningWebObjectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. Materials and methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent … cffsh12-30WebApr 14, 2024 · Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of solid tumours. However, the development of ototoxicity is a serious … bwt coach