WebDescription Rabbit polyclonal to STUB1/CHIP Host species Rabbit Specificity Detects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human gene including a non-specific band at 80kDa . CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery. Mutations in STUB1 cause spinocerebellarataxiatype 16. Interactions. STUB1 … See more STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). See more The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the … See more • Patterson C (Jan 2002). "A new gun in town: the U box is a ubiquitin ligase domain". Science's STKE. 2002 (116): pe4. doi See more STUB1 has been shown to interact with: • C-Raf, • DNAJB1, • HSPA1A, • HSPA4, See more • STUB1 human gene location in the UCSC Genome Browser. • STUB1 human gene details in the UCSC Genome Browser. See more
CHIP/STUB1 Products: R&D Systems
WebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml raised against amino acids 73-303 mapping at the C-terminus of CHIP of human origin Anti-CHIP/STUB1 Antibody (C-10) is recommended for detection of CHIP of mouse, rat and human origin by WB, IP, IF and ELISA gas bottle manufacturers
UniProt
WebSTUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 … WebNov 4, 2024 · Structure of the STUB1 TPR domain in complex with H204, an all-D Helicon Polypeptide WarningYou are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox. Contact us Toggle navigationRCSB PDB Deposit Prepare Data … WebSTUB1/CHIP was also immunoprecipitated by rabbit anti-STUB1/CHIP antibody (Product # A301-573A), which recognizes a downstream epitope. For blotting immunoprecipitated … dave wallace